This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.
| Autorius: | Anastasios Bezerianos, Panos Balomenos, Andrei Dragomir, |
| Serija: | SpringerBriefs in Computer Science |
| Leidėjas: | Springer Nature Switzerland |
| Išleidimo metai: | 2017 |
| Knygos puslapių skaičius: | 96 |
| ISBN-10: | 3319538675 |
| ISBN-13: | 9783319538679 |
| Formatas: | Knyga minkštu viršeliu |
| Kalba: | Anglų |
| Žanras: | Computational biology / bioinformatics |
Parašykite atsiliepimą apie „Computational Methods for Processing and Analysis of Biological Pathways“
