A triterpenoidal compound (P2) has been isolated from anti-inflammatory activity guided fractionation of acetone extract of Drypetes roxburghii leaf with a gradient of methanol in chlroform. Further P2 was screened for anti-inflammatory activity on carageenan and dextran induced inflammation models in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P2 has showed significant reduction in inflammation caused by carrageenan (P>0.01) and dextran (P>0.05). Hence P2 can be considered as the active component responsible for the anti-inflammatory activity of Drypetes roxburghii leaf. The characterization of P2 was done by spectral studies like IR, 1H-NMR, 13C-NMR & Mass Spectroscopy. On the basis of spectral studies the structure of P2 has been elucidated as triterpenoidal compound.
| Autorius: | Vichitra Kaushik, Versha Parcha, Ratan Lal Khosa, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2011 |
| Knygos puslapių skaičius: | 84 |
| ISBN-10: | 3845477822 |
| ISBN-13: | 9783845477824 |
| Formatas: | Knyga minkštu viršeliu |
| Kalba: | Anglų |
| Žanras: | Pharmacology |
Parašykite atsiliepimą apie „Evaluation of Triterpenoidal Anti-Inflammatory Principle: from Drypetes roxburghii Leaves Extract“
