Oral cancer pathogenesis is a complex process involving genetic alteration during multistep carcinogenesis, growth regulation, apoptosis, immortalization, angiogenesis, invasion and metastasis. Molecular markers such as p53, Cyclin-D1 and EGFR regulate cell cycle and play important role in tumor progression and development. The present study evaluates the expressions of these molecular markers & its prognostic significance with treatment response in oral cancer patients undergoing chemoradiation. The strong positive expressions of p53, Cyclin-D1 and EGFR showed significantly lower survival as compared to negative or moderate positive expressions. Hence, expression of p53, Cyclin-D1 and EGFR may serve as a prognostic marker in oral cancer patients.
| Autorius: | Seema Gupta, Huma Khan, Vandana singh Kushwaha, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2015 |
| Knygos puslapių skaičius: | 64 |
| ISBN-10: | 3659672912 |
| ISBN-13: | 9783659672910 |
| Formatas: | Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Expression of p53, Cyclin-D1 & EGFR in oral squamous cell carcinoma: Molecular Marker Expression in Oral Cancer“
