In this study, we present novel insights into mechanisms that account for the ER¿-dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ER¿-overexpression (ER¿-OE), we first demonstrated that this was associated with an increase of LVM at the basal level in both female and male mice. After MI, the cardiomyocyte-specific ER¿-OE inhibited changes in LV-volumes and wall thickness only in female mice. These beneficial effects in female ER¿-OE hearts were associated with increased angiogenesis and lymphangiogenesis, attenuated ventricular fibrosis and enhanced JNK phosphorylation. This study indicates that in the female sex, ER¿ in cardiomyocytes may have a therapeutic potential in the treatment of ischemic heart disease, leading to more efficient cardiac repair after ischemic injury.
| Autorius: | Xiang Zhang |
| Leidėjas: | Südwestdeutscher Verlag für Hochschulschriften AG Co. KG |
| Išleidimo metai: | 2017 |
| Knygos puslapių skaičius: | 92 |
| ISBN-10: | 3838151283 |
| ISBN-13: | 9783838151281 |
| Formatas: | Knyga minkštu viršeliu |
| Kalba: | Anglų |
| Žanras: | Medicine / Healthcare: general issues / topics |
Parašykite atsiliepimą apie „Female sex and ER-alpha modulate cardiac ischaemic remodeling: Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice“
