This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
| Autorius: | Mark J. Van Der Laan, Sandrine Dudoit, |
| Serija: | Springer Series in Statistics |
| Leidėjas: | Springer US |
| Išleidimo metai: | 2010 |
| Knygos puslapių skaičius: | 624 |
| ISBN-10: | 1441923799 |
| ISBN-13: | 9781441923790 |
| Formatas: | Knyga minkštu viršeliu |
| Kalba: | Anglų |
| Žanras: | Computational biology / bioinformatics |
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