This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.
| Autorius: | Florian Frommlet, David Ramsey, Ma¿gorzata Bogdan, |
| Serija: | Computational Biology |
| Leidėjas: | Springer London |
| Išleidimo metai: | 2016 |
| Knygos puslapių skaičius: | 236 |
| ISBN-10: | 144715309X |
| ISBN-13: | 9781447153092 |
| Formatas: | Knyga kietu viršeliu |
| Kalba: | Anglų |
| Žanras: | Computational biology / bioinformatics |
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