MEK inhibition alone was less effective in inducing cytotoxicity than taxanes indicating that a down-regulation of activated ERK1/2 may be necessary but is not sufficient for taxane-induced antitumoral effects. In line with this notion, we show in a xenograft mouse model that prostate cancer cells that are resistant to docetaxel overexpress activated ERK1/2. Taken together, our findings underscore that the modulation of ERK1/2 activation, in concert with other mechanisms, plays an important role in taxane-induced antineoplastic effects on prostate cancer cells.These results suggest at least partially nonoverlapping effects of docetaxel and androgen deprivation therapy and hence help to understand recent clinical findings. A further elucidation of the mode of action of docetaxel would have important implications to optimize current treatment strategies and biomarker development for men with metastatic prostate cancer.
| Autorius: | El Hassane Sidibé |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2019 |
| Knygos puslapių skaičius: | 156 |
| ISBN-10: | 6200460736 |
| ISBN-13: | 9786200460738 |
| Formatas: | Knyga minkštu viršeliu |
| Kalba: | Anglų |
Parašykite atsiliepimą apie „Prostate Proto-Oncogene Molecular Action“
