Non-steroidal anti-inflammatory drugs are one of the commonly prescribed groups of drugs worldwide and are highly effective as analgesic, antipyretic and anti-inflammatory agents. However, their use is also associated with adverse events such as gastro duodenal ulceration and gastro intestinal bleeding. There is always a great need to develop COX-2 specific inhibitors to avoid the side effects. The present report contains a brief introduction to inflammation, biosynthesis of prostaglandins with emphasis on the enzymes COX-1 and COX-2. The main focus is on the literature survey of indan derivatives and experimental work carried out in the laboratory in an attempt to develop newer and less ulcerogenic NSAIDs.
| Autorius: | Biplab Debnath, Prasanta Kumar Sarma, Sudip Kumar Mandal, |
| Leidėjas: | LAP LAMBERT Academic Publishing |
| Išleidimo metai: | 2016 |
| Knygos puslapių skaičius: | 64 |
| ISBN-10: | 3659929026 |
| ISBN-13: | 9783659929021 |
| Formatas: | Knyga minkštu viršeliu |
| Kalba: | Anglų |
| Žanras: | Chemistry |
Parašykite atsiliepimą apie „Synthesis of Few Potential Non-Steroidal Anti-Inflammatory Agents“
